Background: Onlay ventral hernia repair (OVHR) is a well-established technique for repairing ventral hernias by placing a mesh overlay to reinforce the abdominal wall. However, traditional methods of securing the mesh, such as sutures, are associated with prolonged operative time, increased post-operative pain, and complications like mesh displacement. The advent of hernia staplers offers a novel approach to OVHR, potentially addressing these limitations by providing a faster, more secure fixation of the mesh. This study explores the application of a hernia stapler in OVHR and compares its efficacy to conventional suture methods. Materials and Methods: A retrospective analysis was conducted on 100 patients who underwent OVHR between January 2021 and December 2023. Fifty patients were treated with traditional suture fixation (Group A), while the remaining 50 patients underwent mesh fixation using a hernia stapler (Group B). Key variables measured included operative time, post-operative pain (on a Visual Analog Scale, VAS), complication rates (such as seroma, infection, and recurrence), and length of hospital stay. Follow-up was conducted for 12 months post-surgery to assess recurrence and mesh-related complications. Results: The use of the hernia stapler significantly reduced operative time, with an average of 75 minutes in Group B compared to 120 minutes in Group A (p < 0.01). Post-operative pain was lower in the stapler group, with an average VAS score of 3.2, compared to 5.6 in the suture group (p < 0.05). Complication rates were comparable between the groups, with 10% of patients in Group A experiencing minor complications and 8% in Group B. There were no significant differences in recurrence rates between the two groups during the 12-month follow-up period. Conclusion: The use of a hernia stapler for securing the mesh in onlay ventral hernia repair is a promising technique that significantly reduces operative time and post-operative pain without increasing the risk of complications or recurrence. This approach may offer a superior alternative to traditional suture fixation, particularly in cases where time efficiency and patient comfort are prioritized.