Background: The increasing prevalence of diabetes has resulted in concomitant illness. The present study was conducted to assess silver colloidal gel with povidone iodine ointment in patients with diabetic foot. Materials & Methods: 60 patients with diabetic foot ulcer at department of surgery, Shri Guru Ram Rai Institute of Medical and health Science and associated Shri Mahant Indiresh Hospital were divided into 2 groups. Group I: Povidone iodine ointment dressing and group II: Silver colloidal gel dressing. Results: The mean age of the studied patients of group A (Silver colloidal gel) was 52.8±12.7 years whereas that of group B (povidone iodine ointment) 54.3±10.7 years with majority of the studied patients were above 46 years. The majority of the studied patients were having spontaneous mode of onset i.e., 66.7% and 73.3% respectively for group A and B whereas trauma was in 33.3% and 26.7% for Group A and B respectively but the difference was statistically insignificant (p>0.05). The wound size was significantly lower at 4th and 6th week in group A than group B (p<0.05). The wound healing status at sixth week and it was found that amputate was in 3.3% in group A than 6.7% in group B. Grafting was required in 10.0% and 33.3% in group A and B respectively. 56.7% were healed in group A than only 26.7% in group B but the difference was statistically insignificant (p>0.05). The floor status as on 6th week and found that healed/grafting/ flap/amputate/ primary suturing was in 76.7% in group A than 66.7% in group B. The tissue was pale in 20.0% of the group B patients than 0.0% in groups A. Pink tissue were in 23.3% in group A and 13.3% in group B and the difference was statistically significant (p=0.029). The tested swab positive cases with type of organism and found that the majority of the patients were affected by E. coli followed by S. Aureus on both the groups and Klebsiella and Proteus mirabilis in group B but the difference was statistically insignificant (p>0.05). The comparison between outcomes of povidone iodine dressing group and silver dressing group in terms of surface area reduction of wounds and it was found that final area was significantly lower in group A than group B (p=0.039). Percentage reduction in ulcer area was also significantly lower in silver gel group than group B (p<0.001). Conclusion: Silver colloidal gel dressing is preferred over povidone iodine ointment in diabetic foot ulcers.