Aim- To study lipid profile of patients with Alcoholic fatty liver disease and comparing it with the lipid profile of patients with Non Alcoholic fatty liver disease.Material and methods-A total of 100 patients with Fatty Liver disease proven by ultrasound were included in the study, which included 50 Alcoholic patients and 50 Non-alcoholic Patients. Venous blood was drawn from the subjects and Lipid Profile samples sent. Biomarker indices including Total cholesterol, Serum Triglyceride, Serum HDL, Serum LDL and serum VLDL values were evaluated. Data analysis was done using SSPS software.Results- The mean age of patients with ALD and NAFLD was 50.08 years and 44.88 years respectively. Total cholesterol and Serum Triglyceride levels were increased in both the groups but the increase was relatively more in the NAFLD group. HDL levels were decreased in both the groups, but more decreased in NAFLD group. LDL and VLDL were raised in NAFLD group. Serum transaminase levels (SGOT/SGPT) were seen slightly raised in the ALD group. Conclusion- Fatty liver diseases – both Alcoholic fatty liver disease (ALD) and Non-alcoholic Fatty liver disease (NAFLD) have increased risk for significant dyslipidaemia. Although, Lipid profile was deranged in both the groups, but the derangements were more profound in the NAFLD group.