Background: Diabetes mellitus is the most frequently encountered endocrine disorder. The present study was conducted to assess effect of platelet-rich fibrin on extraction socket healing in diabetic patients. Materials & Methods: 50 patients of type II diabetics undergoing dental extraction of two or more teeth of both genderswere divided into 2 groups of 25 each. In group I, the socket was packed with PRF and sutured, and in group II, the socket was sutured without packing. Soft-tissue healing (assessed by colour, bleeding on palpation, granulation tissue, and incidence of suppuration and dry socket)and visual pain scores were assessed. Results: Group I had 12 males and 13 females and group II had 14 males and 11 females. Reddish pink colour at 1 week was seen in 40% and 25%, at 3 weeks in 92% and 57% and at 6 weeks in 100% and 85% in group I and II respectively. Bleeding at 1 week was seen in 45% and 80%, at 3 weeks in 10% and 56% and at 6 weeks in 0% and 15%. Suture margin dehiscence at 1 week was seen in 24% and 48%, at 3 weeks in 0% and 11%. Suppuration at 1 week was seen in 5% and 16%, at 3 weeks in 0% and 7%. Pain at 1 week was 5.6 and 6.4, at 3 weeks was 1.2 and 4.3 and at 6 weeks was 0.3 and 2.5 in group I and II respectively. Conclusion: Both hard-tissue healing and soft-tissue healing were found to be better in the sockets containing PRF.