Topical combination of clobetasol propionate and vitamin D analogues have been commonly used to treat psoriasis vulgaris. However, there is no consolidated information regarding its efficacy and safety.Randomized controlled trials on psoriasis vulgaris using the combination weresearched onPubMed, PubMed Central, and Medline.4 randomized controlled trials with870 participants were included. The trials used topical clobetasol propionate and vitamin D analogues for 6- 26 weeks and were compared withonly vit D analogue or vitamin D analogue / vehicle or vitamin D analogue /betamethasone or only clobetasol propionate.In the first study after 2 weeks treatment with clobetasol propionate and 4 weeks treatment with calcipotriol showed significantly lower overall severity score. (p < 0.0001) than 6 weeks continuous treatment with calcipotriol. In the second study combination is more effective as compared to calcipotriol/vehicle group. (p=0.02).In the third study theoverall severity score at week 2 was significantly lower for combination therapy group as compared to either monotherapy groups (p=0.0017, p < 0.0001). In the fourth study both the treatment modalities like excimer and calcipotriol-clobetasol combination showed significant reduction in MPPPASI score. (0.002)Topical application of clobetasol and vitamin D analogue is more effective in combination as compared to monotherapy with mild adverse events.