Background:Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels.Hence; the present study was conducted for clinico-biochemical profile and treatment response of type 2 diabetics visiting medicine OPD. Materials and Methods:90 patients diagnosed with Type 2 Diabetes (T2D) were enrolled. A significant proportion of the participants (62.2%) were administered two or three oral antidiabetic agents. Metformin emerged as the most frequently prescribed medication, utilized by over 90% of the cohort, followed by sulfonylureas, which were prescribed to 55.7% of the patients. Specifically, 91% of the lean group and 94% of both the normal-weight and overweight/obese groups received metformin. Statistical analyses were performed using the Statistical Package for Social Sciences and Microsoft Excel. Results:In this study, there were 90 subjects of which 35 were females and 55 were males. Total cholesterol levels of lean, normal and overweight diabetic subjects were 182.1±47.6 mg/dl, 180.23±43.9 mg/dl and 181.55±36.9 mg/dl, respectively. Triglyceride levels of lean, normal and overweight diabetic subjects was 184.23±79.5 mg/dl, 178.2 ± 81.4 mg/dl and 186.1 ± 77.7 mg/dl, respectively. Hypertension was present in 15 lean subjects, 7 normal subjects and 28 obese subjects. Neuropathy was seen in 10 lean subjects, 5 normal subjects and 27 obese subjects. Hence; co-morbidities were significantly higher among obese patients. Conclusion:Overweight and obese individuals may experience advantages in glycaemic regulation through reductions in HbA1c levels; conversely, patients of lean and normal weight often present with more pronounced and challenging hyperglycaemia that is harder to manage.