Original Articles
To Study Microvascular Complications and Its Correlation with Duration of Diabetes in Type 2 Diabetes Mellitus Patients in SN Medical College & Hospital, Jodhpur | |
Prabhat Kanvaria, Khushala Ram Choudhary | |
Background: Diabetes mellitus (DM) refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. Most of the burden of T2DM is related to its micro and macro vascular complications.So this study is conducted for timely intervention to prevent these complications and to prevent further deterioration by applying measures to control chronic hyperglycemia.Materials& Methods: A hospital based cross sectional study done on 210 cases of type 2 diabetes mellitus in Upgraded department of medicine, SN Medical College & Hospital, Jodhpur during one year period. The T2DM group was divided into Group I (0-5 years), Group II (6-10 years) & Group III (>10 years) according to the duration of DM type2. Medical histories were obtained for all patients, including details of height, weight, and waist circumference. We also obtained fasting blood glucose (FBG), 2 hour post prandial blood sugar glycosylated hemoglobin (HbAlc), cholesterol lipid (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL),microalbuminurea, nerve conduction study and fundoscopy. Logistic regression would be done to predict microvascular complications on the basis of various independent predictors. The level of significance will be kept at 95% for all statistical analysis. Results: The mean age of study subjects was 58.38 years ranging from 35 to 86 years. The duration of Diabetes ranged from 1 to 22 years with a mean of 10.04 years. The proportion of Microvascular complications increased with increasing age and was highest in >70 years subjects. Patients in the 61-70 years age group had 95.4, 71.6 & 50.8 times higher risk of nephropathy, neuropathy & retinopathy respectively as compared to those under 40 years. The risk of microvascular complications was highest in patients with >10 years of DM. Microvascular complications were more common in patients with HbA1C ≥10% and gradually decreased in lower HbA1C values. Significant association of microvascular complications were seen only with age group and Duration of Diabetes (P<0.05 each). The risk of microvascular complications increased significantly with increasing Duration of DM. Though the proportion of microvascular complications increased with age, but it was not found to be an independent predictor.Conclusion:We concluded that early detection and treatment of these complications therefore plays a crucial role than glycemic control. Detecting these risk factors helps in correcting these at an early stage. Correlation between the various microvascular complications helps in better understanding of their pathogenesis and early control. |
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