Background: Thyroid dysfunction are the most prevalent endocrine problems in the globe. Thyroid hormones are essential for controlling lipid synthesis, metabolism, and mobilization. Circulating lipid levels may change when there is thyroid disease. However, hyperthyroidism are rarely investigated and related to the lipid abnormalities i.e dyslipedmia in Kashmiri Patients. Aims and Objectives: In this study an attempt is made to study lipid abnormalities in hyperthyroidism Patients. Materials and methods: This study was carried out at Post Graduate Department of Physiology in collaboration with Department of Endocrinology, Government Medical College Srinagar. The Lipid profile and thyroid profile of the subjects were assessed by the Abbott (USA) automatic analyzers at Diagnostic Laboratories of SMHS Hospital. A total of 200 subjects (100 cases and 100 controls) were included. The sample size was calculated using a “G” power analysis to detect a significant difference in lipid levels between cases and controls, with an assumed power of 80% and a significance level of 0.05. Controls were selected based on age and sex matching with hyperthyroidism cases, ensuring they were euthyroid with no history of thyroid dysfunction, chronic diseases, or use of lipid-lowering drugs.Data were analyzed using descriptive statistics, t-tests, and chi-square tests to compare lipid profiles. Multivariate logistic regression was performed to assess the association between hyperthyroidism and lipid abnormalities, adjusting for potential confounders. A p-value < 0.05 was considered statistically significant. Results: In this study, hyperthyroid patients (n=100) had significantly lower total cholesterol (145.3 ± 32.1 mg/dL vs. 174.6 ± 28.5 mg/dL; p < 0.001), LDL-C (88.2 ± 21.4 mg/dL vs. 103.7 ± 19.9 mg/dL; p < 0.001), and HDL-C (34.4 ± 9.6 mg/dL vs. 42.3 ± 10.3 mg/dL; p < 0.001) compared to controls (n=100). Triglycerides were elevated in hyperthyroid patients (176.9 ± 37.8 mg/dL vs. 145.2 ± 34.3 mg/dL; p < 0.001), indicating significant dyslipidemia associated with hyperthyroidism. Conclusion In our study we observed subjects with dyslipidemia, a thyroid function test is crucial for the detection of thyroid dysfunction. It is also crucial for any individuals whose lipid profile unexpectedly improves or deteriorates. Therefore, patients with dyslipidemia who have underlying thyroid abnormalities should be identified and treated, particularly if the results are unexpected.