Background: The paediatric population's functional residual capacity is low, and oxygen consumption is high. Hence, these patients desaturate very fast. During the administration of general anaesthesia, pre-oxygenation takes care of oxygen requirement until laryngoscopy. And then, the patient will start receiving oxygen only after intubation and connecting to the breathing circuit. The concept of apneic oxygenation comes to the rescue during unanticipated difficult airways or during prolonged intubating conditions. Methodology: In this prospective randomized clinical trial, 116 with age, weight, and sex-matched were assigned a group using computerized random table numbers into the standard care (SC) group and apnoeic oxygenation (approx) group with 58 patients in each group. The apneic oxygenation group was provided 4ltrs of oxygen through a buccal cannula during intubation, while the Standard group was intubated without oxygenation during intubation. Results: The mean heart rate from baseline, immediately after preoxygenation, is not significant, but after 1 minute to 5 minutes, results were statistically highly significant. (P-value<0.0001).Mean arterial pressure and mean oxygen saturation were statistically significant. (P-value<0.0001) at 2, 3 and 5 minutes after preoxygenation. The time taken for desaturation in the ApOx group and the standard group started after 2 minutes, but it was longer in the ApOx groups compared to standard care. In the ApOx group, desaturation was observed at 3%, but in standard care groups, it was observed at 5%, and the majority of the patients were desaturated by only 1% in the ApOx group compared to the standard care group. Conclusion: There was a statistically significant difference observed in safe apnoea time with saturations up to 95% between the groups. Low mean oxygen saturation was observed in standard care groups compared to the ApOx group.