Background: Schizophrenia is a chronic illness with antipsychotic medications considered as first-line of treatment. Effective management requires a long-term treatment with mediations. Non-adherence to medications is an important area of concern as it can lead to higher disability, relapse and rehospitalization in patients with schizophrenia. Multiple factors determine medication adherence and understanding these can help in improving patients’ compliance to prescribed medications. Aims: The aim of this study was to find the reasons of non-adherence and also the attitude of patient towards medications. Materials and Methods: The study was conducted on 40 follow up patients presenting to out-patient and in-patient setup of Department of Psychiatry, AVBRH, Wardha, who were diagnosed with Schizophrenia and fulfilled the Rosack’s Criteria for Non-adherence. The study was conducted over a period of 6 months. Their socio-demographic details were noted. Attitude towards medication was assessed using the Drug Attitude Inventory Scale (DAI-10), and the reasons for non-adherence were assessed using Rating of Medication Influences scale (ROMI). Results: out of 40 participants, 70% of them were found to be non-compliant. the mean DAI-10 score of non-complaint participants (2.08 ± 0.39) was lower when compared with that of the compliant group (6.35 ± 0.30). Financial obstacles, denial of illness, stigma of medication use and feeling that medications are unnecessary were reported to be the most significant reasons on non-compliance among others. Conclusion: It can be suggested from the findings, that patients and relatives should be given a detailed explanation about the nature and course of illness, prognosis, need for treatment and treatment duration. Development of community mental health care facilities in rural areas can also help in improving patients’ adherence to medications.