Background:To studythe spectrum of hepatic abnormalities including sero-prevalence of hepatitis b and hepatitis c coinfection in HIV infected individuals and their correlation with cd4 count.There had been little work done on liver function tests in HIV patients without pre-existing liver disease. Method: An observational study was conducted on 200 HIV patients above 18 years of age andexcluded those who were already diagnosed with Hep B or Hep C, co-existing malignancy, obstructive biliary disease and those with heavy alcohol consumption. Result: In our study Sero-prevalence of Hepatitis B co-infection among HIV Individuals was 4% (n=8). In our study Sero-prevalence of Hepatitis C co-infection among HIV Individuals was 15% (n=30). In our study Sero-prevalence of Hepatitis B and Hepatitis C co-infection among HIV Individuals was 1.5% (n=3). Overall, 34% (n=68) patients had abnormal Liver Function Tests.Out of 200 patients studied, 13 patients (6.5%) had serum bilirubin of more than 1 mg/dl and 187 patients (93.5%) had serum bilirubin in normal range.137 patients (68.5%) had AST level up to 40 IU/L and 63 patients (31.5%) had AST level of more than 40 IU/L. Out of these 63 patients, 61 patients (96.8%) were on TLE regimen and 2 patients (3.2%) were on ZLN regimen. Probable etiologies for deranged AST level in 63 patients were HIV/HBV co-infection in 7.9% patients (n=5), HIV/HCV co-infection in 28.6% patients (n=18), NAFLD in 9.6% patients (n=6) and HIV infection itself or cART or unknown causes in the remaining 53.9% patients (n=34). Conclusion: Elevated liver transaminases are now a common finding in HIV-infected patients. The main etiologies for hepatic morbidities in HIV-infected patients includes viral hepatitis coinfection, NAFLD, ARTrelated liver injury and infection-related factors. Thus, regular liver function tests along with non-invasive methods of investigation of hepatobiliary system needs to be done in every individual infected with HIV.