Background: Alcohol dependence frequently co-occurs with anxiety and depression, exacerbating the challenges of treatment and recovery. This study aims to assess the impact of anxiety and depression on individuals with alcohol dependence using the Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD). Methods: Conducted at a tertiary care center in the Marathwada region of Maharashtra from February to May 2024, this study involved 141 participants diagnosed with alcohol dependence. Participants were assessed using the HAMA and HAMD scales to measure the severity of anxiety and depression. Demographic data and clinical history were collected to identify correlations between these variables and mental health conditions. Statistical analyses, including Chi-square tests and Pearson correlation coefficients, were used to evaluate the relationships between variables. Results: The study found that 16.31% of participants had severe anxiety (HAMA scores ≥31) and 28.37% had moderate to severe depression (HAMD scores ≥31). A significant correlation was observed between the duration of alcohol dependence and the severity of anxiety and depression. Participants with longer durations of dependence exhibited higher HAMA and HAMD scores. Additionally, higher levels of anxiety and depression were associated with increased relapse rates and poorer treatment outcomes. Conclusion: The findings underscore the high prevalence of anxiety and depression among individuals with alcohol dependence and highlight the need for integrated treatment approaches that address both conditions. Effective management of alcohol dependence should include strategies to reduce anxiety and depression to improve treatment outcomes and reduce relapse rates.