Objective: This study provides the knowledge, attitudes, and practices of doctors regarding generic medicines across government hospitals and institutions in Chhattisgarh, Central India. Methods: A cross-sectional survey was conducted from February to April 2024 using a 26-question electronic questionnaire administered to doctors in government hospitals and institutes in Chhattisgarh. Data from 67 participants was analyzed using descriptive statistics. Results: Most respondents (72%) frequently prescribe generic medicines. However, 72% expressed concerns that switching from brand-name to generic drugs might affect therapeutic outcomes. Medical representatives influence 60% of doctors' prescribing habits. A majority (84%) were comfortable with pharmacists substituting branded medications with generics. Additionally, 64% noted that patients' socioeconomic status impacts their prescribing practices, and 76% had personal experience with generic medicines. Conclusion: The study demonstrates a general acceptance of generic medicines among doctors in Chhattisgarh, although concerns about efficacy and safety persist. Increased awareness, supportive policies, and pharmacist involvement are essential for promoting rational use and improving patient outcomes.