Background: Gall stones are one of the most common disorders of the gastrointestinal tract, affecting about 10% of people in Western society. The present study was conducted to assess incidence of post cholecystectomy syndrome in a tertiary care centre. Materials & Methods: 245 patients of post cholecystectomy syndrome both genders in department of general surgery, Sharda Hospital, School of Medical sciences and Research were selected. The details of surgery were documented; and once discharged, these patients were followed up for 6 months. On follow-up, symptoms, if any, were documented and investigated only if they persisted beyond 1 month of surgery. Results: There were 17.1% males and 82.9% females. At 1st month follow-up, bloating was seen among 1.2%, burping among 0.8%, epigastric pain among 8.2%, indigestion among 1.2%, loss of appetite among 0.4% and nausea and vomiting among 2.4%. At 2nd month follow-up, epigastric pain was seen among 5.3%, indigestion among 1.2%, and nausea and vomiting among 0.8%. At 3rd month follow-up, epigastric pain among 0.4%, indigestion among 0.8%, and nausea and vomiting among 0.4%. At 4th month follow-up, epigastric pain among 0.4% and indigestion among 0.4%. At 5th month follow-up, epigastric pain among 1 (0.4%) subject. At 6th month follow-up, epigastric pain among 1 (0.4%) subject. Conclusion: After Laparoscopic Cholecystectomy, less than half of patients will experience some symptoms; dyspeptic symptoms are the most frequent and last for quite some months; early signs include biliary and intestinal problems, both of which are temporary. Patients who have experienced acute cholecystitis episodes in the past or who have co-morbid illnesses are more likely to experience prolonged symptoms. Only individuals with persistent symptoms and no clear cause on examination should be classified as PCS since very few patients (less than 1% in the current study) had a discernible cause of symptoms.