Aim: The study aimed to utilize clinical, hematological, and ultrasonographic criteria to predict the difficulty of laparoscopic cholecystectomy and the potential need for conversion to open cholecystectomy (OC) prior to surgery. Materials and Methods: The study involved 60 cases of laparoscopic cholecystectomy and evaluated the duration of surgery, access to the peritoneal cavity, gallbladder bed dissection, difficult extraction, and the need for conversion to open cholecystectomy as dependent variables or outcomes. Data analysis was done using SSPS software. Results: The analysis of the surgeon's assessment in the study revealed that the majority of cases, 70%, were classified as easy, with 16.67% categorized as difficult, and 13.33% identified as very difficult. Conclusion: Preoperative evaluation has the potential to predict the likelihood of a challenging laparoscopic cholecystectomy (LC). This predictive information is valuable for both the patient and the treating surgeon in preparing for the surgery effectively.