Aim: To evaluate the effectiveness of topical hyaluronic acid in promoting wound healing, as compared to betadine. Materials and Methods: The study was conducted at our hospital, involving 60 patients who were randomly allocated into two groups: the test group and the control group, each consisting of 30 subjects. Patients in the test group received topical hyaluronic acid during wound dressings, while those in the control group were treated with conventional Povidone-Iodine (Betadine) dressings. Both groups received appropriate parenteral antibiotics as per the hospital's antibiotic policy. Subjects in both groups underwent daily wound dressings under strict aseptic precautions. The test group received 7 days of daily hyaluronic acid dressings. At the end of 7 days, all subjects were assessed for percentage reduction in the surface area of the ulcer, presence or absence of granulation tissue, slough, and discharge, and wound assessment using the Bates-Jensen Wound Assessment Tool, which evaluates parameters such as size, depth, edge, undermining, necrotic tissue type and amount, exudate type and amount, skin color surrounding the wound, peripheral tissue edema and induration, granulation tissue, epithelialization, location, and shape. Results: The Bates-Jensen Wound Assessment Tool (BWAT) scores at day 7 revealed significant improvements in the test group compared to the control group. The size score was lower in the test group (3.2 ± 0.9) compared to the control group (4.1 ± 1.0), with a p-value of 0.01. Depth scores were 2.9 ± 0.8 in the test group and 3.7 ± 0.9 in the control group, with a p-value of 0.02. Edge scores were 3.1 ± 0.7 in the test group and 3.8 ± 0.8 in the control group, with a p-value of 0.03. Necrotic tissue type and amount scores were significantly lower in the test group (2.5 ± 0.6 and 2.7 ± 0.6) compared to the control group (3.2 ± 0.7 and 3.3 ± 0.8), with p-values of 0.04 and 0.05, respectively. The percentage reduction in the surface area of ulcers was significantly greater in the test group. At day 7, the test group showed a 35.2% ± 10.5% reduction, while the control group showed a 25.3% ± 9.8% reduction, with a p-value of 0.01. By day 14, the test group had a 48.6% ± 12.3% reduction compared to a 36.4% ± 11.6% reduction in the control group, with a p-value of 0.02. The presence of granulation tissue, slough, and discharge was also assessed. Granulation tissue was present in 86.67% of the test group compared to 66.67% of the control group, with a p-value of 0.05. Slough was observed in 16.67% of the test group and 40% of the control group, with a p-value of 0.04. Discharge was noted in 23.33% of the test group versus 50% of the control group, with a p-value of 0.03. Conclusion: Overall, the study demonstrated that topical hyaluronic acid significantly improved wound healing outcomes compared to Betadine, as evidenced by better BWAT scores, greater reduction in ulcer size, and lower rates of postoperative complications.