Aim: To analyze the clinical characteristics of patients with ulcerative colitis and evaluate their response to therapy. Material and Methods: The study included a total of 100 patients diagnosed with ulcerative colitis, confirmed through clinical evaluation, endoscopic findings, and histopathological examination. Patients aged 18 years and above, both male and female, were included in the study. Inclusion criteria were adults aged 18 years and older, a confirmed diagnosis of ulcerative colitis through clinical, endoscopic, and histopathological findings, and patients who provided informed consent. The clinical history included symptoms such as abdominal pain, diarrhea, rectal bleeding, weight loss, and fever; duration of illness; extent of disease (proctitis, left-sided colitis, pancolitis); severity of disease (mild, moderate, severe); and extraintestinal manifestations such as arthritis, skin lesions, and eye involvement.Treatment details encompassed medications (aminosalicylates, corticosteroids, immunosuppressants, biologics), dosage and duration of treatment, response to treatment (categorized as complete response, partial response, or no response), and adverse effects of medications. Results: In terms of symptoms, 80% of the patients experienced abdominal pain, 90% had diarrhea, 70% reported rectal bleeding, 60% suffered from weight loss, and 30% had fever. The duration of illness varied, with 20% of patients having the disease for less than 6 months, 40% for 6-12 months, and another 40% for more than 12 months. The extent of the disease showed that 20% of the patients had proctitis, 50% had left-sided colitis, and 30% had pancolitis. Disease severity was categorized as mild in 30% of patients, moderate in 50%, and severe in 20%. Additionally, 20% of patients had arthritis, 15% had skin lesions, and 10% had eye involvement as extraintestinal manifestations.Regarding treatment, 80% of the patients were on aminosalicylates, 60% on corticosteroids, 30% on immunosuppressants, and 20% on biologics. The response to treatment was classified as complete in 50% of patients, partial in 30%, and no response in 20%. Adverse effects of medications were reported by 30% of patients, while 70% did not experience any adverse effects. Conclusion: We concluded that the abdominal pain and diarrhea were the most common symptoms, with a significant portion experiencing rectal bleeding and weight loss. The extent and severity of the disease varied, with left-sided colitis and moderate disease being the most prevalent. Treatment predominantly involved aminosalicylates and corticosteroids, with a notable response rate, although adverse effects were reported by a minority.