Introduction:Regional anaesthesia offers precise, efficient, and long-lasting anaesthesia and analgesia. It is often used as a supplement to general anaesthesia or as a primary method. With the invention of newer, safer local anaesthetics, regional anaesthesia has been the primary technique for procedures on the upper limbs. This study is aimed at comparing the effects of dexmedetomidine 50mcg as an adjuvant to 0.5% Bupivacaine in Interscalene brachial plexus blocks. Methodology: This is a hospital based prospective, double blinded study conducted on 60 patients of age of 18-60 years who were selected for arm surgeries with interscalene brachial plexus block.The selected patients were divided randomly into two groups of 30 each. This study was carried out between January 2021 and December 2022. The statistical analysis was carried out using excel sheet to spread the data and SPSS Version 22.0,Mean ± SD used for descriptive statistics. While categorical variables were compared using chi-square test, continuous variables were compared using the independent samples t test, and the data was represented with tables and figures wherever applicable. Results: The duration of onset of sensory-blockade is reduced when dexmedetomidine is added to Bupivacaine in Interscalene brachial plexus block. The duration of motor and sensory block is also prolonged when dexmedetomidine is added to Bupivacaine in Interscalene brachial plexus block. Time of analgesia is also prolonged when dexmedetomidine is added to bupivacaine in brachial-plexus block. Sedation is also better in the dexmedetomidine group.