Background: Globally, there is a rise in endocrine disorders. Thyroid diseases rank among the most common endocrine conditions worldwide, second only to diabetes mellitus.The present study was conducted to assess lipid profile in patients with sub clinical hypothyroidism. Materials & Methods: 55 patients with sub clinical hypothyroidism of both genders were kept in group I and healthy controls in group II. All were subjected to assessment of thyroid profile such as T3, T4, TSH, TC, TGL, LDL, and HDL. Results: Out of 55 patients, males were 30 and females were 25. In group I and group II, the mean T3 was 4.8 and 5.9, T4 was 12.4 and 15.7, TSH was 9.3 and 2.6, TC was 238.5 and 157.3, TGL was 165.2 and 95.8, LDL was 188.4 and 97.2 and HDL was 34.1 and 41.5 respectively. The difference was significant (P< 0.05). Conclusion: There was high level of lipid profile in patients with subclinical hypothyroidism. Therefore, the estimation of lipid profile should be made as a routine investigation in all cases of subclinical hypothyroidism.