This study explores the potential radioprotective effects of 2-deoxy-D-glucose (2-DG) combined with grape seed (Vitis vinifera), green tea (Camellia sinensis), and ginger (Zingiberofficinale) extracts on radiation-induced oxidative stress in mice. Through the assessment of nitric oxide levels, lipid peroxidation, and antioxidant enzyme activities in kidney cells, the research unveils significant protection against radiation-induced damage. These findings emphasize the promise of these combinations as potent radioprotective agents, offering potential avenues for further research and clinical application.