This study investigates the combined effects of 2-deoxy-D-glucose (2DG) with grape seed (Vitis vinifera), green tea (Camellia sinensis L.), and ginger (Zingiberofficinale) extracts on antioxidant activity during radiotherapy in mice. The research measures concentrations of α-tocopherol, ascorbate, total flavanols, total antioxidant activity, and reducing power in individual and combined extracts. Results indicate that combined extracts significantly enhance antioxidant activity, suggesting a synergistic effect that could potentially mitigate radiation-induced oxidative stress.