Aim: The aim of this study was to determine the influence of various irrigants on bond strength of adhesive systems to dentin. Material and methods: This study utilized 60 intact human premolars to investigate the impact of different endodontic irrigants on the micro-tensile bond strength (µTBS) of a self-etch universal adhesive system for composite restoration. Data analysis was done using SSPS software. Results: The groups treated with EDTA followed by NaOCl showed significantly lower bond strength compared to the other two groups in the study. Conclusion: Considering the constraints of this study, the control group exhibited notably reduced bond strength in comparison to the groups under comparative conditions.