Background: Depending on where the cyst's epithelial lining originated, cysts that occur in the oral and maxillofacial region can be categorized as either nonodontogenic or odontogenic. The present study was clinico- pathological analysis of odontogenic cysts. Materials & Methods: 80 cases of odontogenic cysts of both genders were selected. Radiographs were analyzed for the location, peripheral shape, and pathologies associated with cystic lesions; the maxilla and mandible were divided into anterior and posterior anatomic regions; hematoxylin/eosin-stained slides of odontogenic cysts or nonspecific cysts were examined; the type and number of cysts, as well as lesion location, were noted. Results: Out of 65 patients, males were 33 and females were 32. The common cyst was dentigerous cyst in 10 cases. OKC in 12, gingival cyst in 7, Botyroidodontogenic cyst in 3, radicular cyst in 24, residual cyst in 7 and lateral periodontal cyst in 2 cases. Maxillary anterior region was involved in 28 cases, posterior region in 12, mandibular anterior region in 10 and posterior region in 15 cases. Pathologies were root resorption in 7 and displacement of tooth/root in 14 cases. The difference was significant (P< 0.05). Conclusion: Radicular cyst, residual cyst, dentigerous cysts, OKCs, and gingival cysts were the most prevalent odontogenic cysts. Other cysts identified were lateral periodontal cyst, and botyroidodontogenic cyst. The majority of cases involved the maxillary anterior area.