Background:By attenuating autonomic nervous activity, myocardial depression, and vasodilatation, general anesthetic induction drugs can lower arterial blood pressure. The present study was conducted to assess hemodynamic changes with Propofol and Etomidate during general anaesthesia. Materials & Methods:64 patients scheduled for surgical procedure under general anaesthesiaof both genderswere divided into 2 groups of 32 each. Group I patients received Propofol, and group II received Etomidate. All the patients were premedicated with alprazolam 0.25 mg and ranitidine 150 mg one night before the surgery. All the hemodynamic parameter was recorded during the surgery procedure. Results: Group I had 20 males and 12 females and group II had 16 males and 16 females. The mean heart rate (beats/min) at baselinewas 84and 85, at induction was 85 and 88, at laryngoscopy was 86 and 88, at one minute was 88 and 90, at five minutes was 86 and 89 and at fifteen minutes was 88 and 89. The mean arterial pressure (mm Hg) at baseline was 94 and 96, at induction was 105 and 94, at laryngoscopy was 97 and 95, at one minute was 98 and 92, at five minutes was 90 and 92 and at fifteen minutes was 92 and 91 in group I and II respectively. The difference was significant (P< 0.05). Conclusion: Etomidate was discovered to be a more effective anesthetic agent than propofol.