Aim: The aim of the study was to compare the quality of Anaesthesia provided by the combination of midazolam and fentanyl versus midazolam and propofol in patients undergoing surgeries under regional Anaesthesia. Materials and methods-The study involved 100 patients with ASA Grade I, II, and III, who were randomly divided into two groups of 50 patients each. The study compared the use of midazolam with fentanyl in group A and midazolam with propofol in group B for conscious sedation. Quality of Anaesthesia was compared in terms of sedation score. Data analysis was done using SSPS software. Results- In comparing the results of sedation scores between Group A (Midazolam + Fentanyl) and Group II (Midazolam + Propofol), it is evident that Group B (Midazolam + Propofol) achieved better overall results. Conclusion-Our study indicates that the quality of sedation achieved with Midazolam plus Propofol is significantly superior to that achieved with Midazolam plus Fentanyl.