Background: The present study was conducted to assess the efficacy of curcumin in the management of Oral Submucous Fibrosis (OSF). Material and methods: 50 clinically diagnosed patients with OSF who ranged in age from 18 to 50 years and had an interincisal opening between 15 and 30 mm were chosen. One month before the start of treatment, the patients were urged to give up all tobacco and areca usage habits. 30 of the 50 cases were men and 20 were women. Before starting a medication regimen for the trial, all 50 subjects were requested to stop all behaviours connected to tobacco and areca use as well as any OSF treatments for a period of one month.The subjects were assessed based on the baseline assessment criteria, which measured the patient's state at the beginning of the study and would be reassessed at further study visits. Out of 50, 25 subjects had been given curcumin for treatment and other 25 subjects had been treated with topical steroid application and were called as the control group. Statistical analysis was conducted using SPSS software. Results: The inter-incisal distance at baseline, 3 months, 6 months and 9 months in steroid group was 25.47+1.26, 27.11+1.14, 28.32+1.09 and 29.64+1.00, respectively. The interincisal distance at baseline, 3 months, 6 months and 9 months in curcumin group was 23.69+2.19, 29.23+1.56, 30.75+1.98 and 31.78+2.45, respectively. Conclusion: Curcumin administration as compared to steroid application proved to be a better treatment approach for OSMF.