Background: Oral health conditions have an impact on Quality of Life as they influence how people enjoy life in terms of appearance and function, such as speech, chewing, nutrition and self-esteem thus affecting the physical and psychological wellbeing of an individual. The instrument Oral Impacts on Daily Performances (OIDP) focuses on measuring the serious oral impacts on the person’s ability to perform daily activities. Aim: To assess the Oral Health Related Quality of Life (OHRQoL) in adult patients attending a dental institution by using OIDP scale. Methodology: A descriptive cross-sectional study was conducted among 216 patients visiting the dental hospital selected by simple random sampling method. Data was collected using close-ended self-administered questionnaire and oral examination and statistically analyzed using factorial ANOVA. Difference between two groups was determined using student t-test and the level of significance was set at p < 0.05. Results: The mean OIDP score of 216 subjects was 35.44±20.03 whereas the highest mean score was for eating (10.45±8.87) and the lowest mean score was for working (1.24±3.49). Statistically significant association was found between the mean OIDP scores and socio-economic status, self-rated oral health status and missing teeth. Conclusion: OIDP was found to be highly prevalent among the study subjects and oral problems had a greater impact on their daily activities affecting the OHRQoL severely in the present study.