Aim: The aim of this study was to compare the clinical profile of patients with epilepsy based on the presence or absence of psychiatric comorbidity. Material and methods: This research was conducted at the Psychiatry Department of Rohilkhand Medical College & Hospital (RMCH), Bareilly, a tertiary care centre in Uttar Pradesh, India. The study included a total of 100 epileptic patients who met the inclusion and exclusion criteria. Purposive sampling was used to recruit patients aged 18 years or older, suffering from epilepsy, and in the inter-ictal period, approval for the studywas taken from the Institutional Ethical Committee. Results: The mean age of patients with psychiatric comorbidity (32.67±9.50 years) was significantly higher (t = 2.931, df = 98, p<0.05) than those without psychiatric comorbidity (28.79±9.21 years). Patients with epilepsy and psychiatric comorbidity had a significantly higher mean GHQ12 score (13.76±8.191) than those without psychiatric comorbidity (10.51±6.385), as shown by independent samples t-test (p<0.05). A significantly higher number of patients with epilepsy with first or second degree relatives suffering from psychiatric disorder were found to be suffering from a psychiatric disorder (χ2=9.82; df=1; p<0.05). However, there was no significant group difference between patients with epilepsy with and without psychiatric comorbidity in terms of other clinical variables, such as age of onset of seizure, duration of epilepsy, type of seizures, etiology, age of onset (in years), duration of epilepsy (in years), seizure frequency, family history of seizure, and past history of mental disorder. Conclusion: The study suggests that patients with epilepsy commonly experience mental comorbidity, including personality disorders. Therefore, it is essential to recognize the multifaceted nature of mental comorbidity in epilepsy patients to improve therapy, outcomes, and policy-making.