Connective tissue or Systemic autoimmune Rheumatic diseases are characterized by autoantibodies that can affect tissues and organs throughout the body. There are more than 200 types of connective tissue diseases. This case series presents management of Abnormal uteruine bleeding, chronic pelvic pain in 3 cases, 2 cases of Mixed connective tissue disorder and 1 case of Polymyositis.Hysterectomy in a patient with Connective tissue disorder for gynaecological indications example severe menstrual bleeding, fibroids, adenomyosis requires careful preoperative planning and coordination among various medical & surgical specialties. Surgical Management of these patients require availability of HDU,ICU and multi disciplinary team approach.