Aim:To determine the effectiveness of Magnesium Sulphate and Dexmedetomidine in inducing controlled hypotension for Functional Endoscopic Sinus Surgery.Material and Methods: A total of 100 patients were recruited for the study and were separated into two equal groups using random assignment: the dexmedetomidine group (n=50) and the MgSO4 group (n=50). The research included patients of both genders, aged 18-60 years, who were scheduled to undergo FESS (Functional Endoscopic Sinus Surgery) under general anesthesia. Only patients classified as ASA grade 1 or 2 were included. Demographic parameters such as gender, age, weight, ASA grade, and operation length were compared between both groups. Hemodynamic parameters, such as Heart Rate (HR), Mean Arterial Pressure (MAP), Systolic Blood Pressure (SBP), and Diastolic Blood Pressure (DBP), were assessed at several time points: baseline, after premedication, after administration of the study drug, during induction or intubation, and after 5 minutes, 10 minutes, 15 minutes, 30 minutes, 60 minutes, and 120 minutes.Results: The baseline HR was not significantly different between the groups (p=0.13), significant differences emerged post-administration of the study drug and continued through various time points. Post-administration HR was significantly lower in Group D (68.25 ± 7.16) compared to Group M (70.22 ± 6.48), with a p-value of 0.04. These differences were even more pronounced at 5 minutes (p=0.009), 10 minutes (p=0.002), 15 minutes (p=0.001), 30 minutes (p=0.005), 60 minutes (p=0.01), and 120 minutes (p=0.02), indicating better control of HR in the Dexmedetomidinegroup.Similar to heart rate, MAP was generally lower in Group D compared to Group M at most time points. DBP followed a similar trend to SBP, being generally lower in Group D. Surgeon satisfaction was higher in Group D compared to Group M. In Group D, 30% of surgeons rated the satisfaction as "Excellent" and 50% as "Good", whereas in Group M, 20% rated it as "Excellent" and 40% as "Good". Group D had fewer "Poor" (10%) and "Moderate" (10%) ratings compared to Group M (16% and 24%, respectively). The bleeding score results show significant differences between Group D (Dexmedetomidine) and Group M (Magnesium Sulfate) in terms of intraoperative bleeding.Group D had fewer cases of higher bleeding scores compared to Group M, indicating better bleeding control.Conclusion: We concluded that dexmedetomidine is superior to magnesium sulfate in managing intraoperative hemodynamic parameters, minimizing intraoperative bleeding, and improving surgeon satisfaction during functional endoscopic sinus surgery (FESS).