Background:A perianal fistula is a condition characterized by an abnormal connection between the skin around the anus and the anal canal or rectum. Hence; the present study was conducted for assessing the efficacy of marsupialization on Fistulotomy wound edges among patients with simple perianal fistula.Materials and Methods:100 patients with simple peri-anal fistulas underwent fistulotomy, with Group A receiving the procedure without marsupialisation and Group B with marsupialisation. The study focused on patients with simple non-recurrent perianal fistulas falling under ASA I and II, excluding cases with secondary or complex fistulas, anal incontinence, prior anal surgeries, or factors influencing wound healing. Statistical analysis was conducted using the SPSS program. Results: Group A, which underwent fistulotomy, had a significantly shorter operative time compared to group B, which underwent fistulotomy and marsupialization. Late postoperative pain at one week was significantly better in group B. There were no significant differences between the groups in terms of complications such as bleeding, incontinence, and urine retention. Conclusion: Marsupialization of the skin edges of anal fistulotomy wound, despite potentially increasing surgical duration, significantly improves wound healing and reduces long-term postoperative pain without elevating the risk of other complications.