Background: In the early days, acute cholecystitis (AC) was listed as a contraindication to laparoscopic cholecystectomy (LC). Presence of acute inflammation, difficulty in dissection, and higher chances of complications were initial apprehensions. the present study was conducted for evaluating the effectiveness of Diclofenac and Dexmedetomidine on Preoperative Hemodynamics and Post Operative Analgesia for Patient Undergoing Laparoscopic Cholecystectomy. Materials & Methods: A total of 50 patients belonging to either sex with American Society of Anesthesiologists (ASA) physical status I/ II and scheduled for elective laparoscopic cholecystectomy were enrolled. Complete demographic and clinical details of all the patients were obtained. The intensity of the pain was assessed using visual analogue scale (VAS) at 0.5 h, 1 h, 4 h, 6 h. Where zero score corresponds to 'no pain' and 10 corresponds to the 'maximum' or 'worst pain'. Rescue analgesia was given in the form of inj. diclofenac sodium 75 mg i.v. at VAS >3. Total analgesic consumption in the first 24 h postoperatively and occurrence of nausea, vomiting and sedation were also recorded. Results: Mean duration of surgery of the patients was 40.65±10.70min. Although, heart rate also decreased, it remained nearer to the baseline values and returned to baseline at 6-hours. Systolic BP started decreasing significantly in comparison to baseline (P<0.01). It came back to baseline at 4-hours. Diastolic BP started decreasing in comparison to baseline (P<0.01). VAS score significantly improved over postoperative time. Conclusion: Diclofenac combination with dexmedetomidine showed hemodynamic maintenance and significant reduction in pain score.