Background: Erectile dysfunction (ED), defined as the consistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance. The present study assessed the effects of Tadalafil in Erectile Dysfunction. Materials & Methods: 117 patients in Urology OPD of Superspeciality Block and Sanjay Gandhi Memorial Hospital associated with Shyam Shah Medical College, Rewa (M.P.) during of 1st Feb. 2020 to 31st July 2021 (18 months)were prescribed 5mg tadalafil daily for three months. At the end of this period, the patients were re-evaluated using IIEF-5, IELT and IPSS. Results: The mean age of all patients was 35.22 years with a minimum age being 20 years and maximum age being 55 years. Maximum patients (53) were between 31 to 40 years accounting to 45.30%. Out of 117 patients in the study, 30 patients were among the age range of 41-60 years, accounting to 25.64%. Diabetes mellitus was seen in 13, LUTS in 11, dyslipidemia in 3, physical anomaly in 0 and BPH in 19 patients. Mild ED had maximum patients (11) in age group 31-40 years, moderate (29) in age group 31-40 years and severe in age group 31-40 years (13). Out of 21 mild ED, 3 had DM, out of moderate ED, 9 had DM, and out of 20 severe ED, 1 had DM.LUTS was present in 9 moderate and 2 severe ED. Conclusion: A daily dose of 5mg tadalafil can be safely used in the treatment of erectile dysfunction and LUTS, that prolongs the ejaculatory latency time.