Background: Over the past ten years, there has been a noticeable rise in the number of patients with ocular allergies, a condition that is frequently encountered in clinical practice. The present study compared management in cases of allergic conjunctivitis. Materials & Methods: 80 patients with allergic conjunctivitis of both genders were classified into 2 groups of 40 each. Group I patients were prescribed topical 0.1% Olopatadine eyedrops BID and group II patients were prescribed topical 0.25% Alcafatadine eyedrops BID. Itching, redness, discharge andforeign body sensation were recorded. Results: In group I, 14 patients and in group II 20 patients, on 1 day, 32 patients in group I and 36 patients in group II, and on 1 week, all 40 patients in both groups recovered from redness. The difference was significant (P< 0.05). At 15 minutes, 1 day and 1 week, 7 patients in group I and 11 in group II, 35 in group I and 38 in group II and 40 in group I and II recovered foreign body sensation. The difference was non- significant (P> 0.05). At 15 minutes, 4 patients in group I and 7 in group II, on 1 day, 17 in group I and 28 in group II and on 1 week, all 40 patients recovered from discharge. The difference was non- significant (P> 0.05). Conclusion: Both medications were found to be efficient for allergic conjunctivitis patients.