Background: Neonatal period is the most vulnerable period of life due to different diseases, especially in preterm and low birth weight babies. The present study was conducted to assess neonatal outcome of the patients admitted in NICU. Materials & Methods:140 neonates of both genders were included and parameters such as mode of delivery, birth weight, gestational age, inborn or outborn delivery, indication for admission, bacteriological profile, investigations such as C-reactive protein (CRP), complete blood count (CBC), positive blood culture and cerebrospinal fluid (CSF) examinationand outcome after hospitalization in NICU was recorded. Results: Out of 140 patients, males were 80 and females were 60. Etiology of NICU admission was sepsis in 30, respiratory distress in 54, birth asphyxia in 16, hypoglycemia in 8, neonatal hyperbilirubinemia in 20, cardiac anomaly in 7 and congenital anomaly in 5 cases. The difference was significant (P< 0.05). Gestational age was <34weeks in 64, 34–36.6weeks in 46 and >37weeks in 30. Birth weight was 1500grams in 75, 1500-2500grams in 42 and>2500grams in 23. Mode of delivery was vaginal in 58 and caesarean in 82. The difference was significant (P< 0.05). Conclusion: The most common indication forNICU admission was sepsis, respiratory distress, birth asphyxia, hypoglycemia, neonatal hyperbilirubinemia, cardiac anomalyand congenital anomaly.