Abstract Issue

Volume 12 Issue 4 ( October-December ) 2023

Original Articles

Association of virulence factors with antifungal resistance in candidaspecies isolated from various clinical specimens
Brij N. Singh, Saumya Singh, Devesh Sharma, Nandlal Kumar, Pratima Kumari

Background: Candidaspecies are opportunistic pathogenic fungi, most frequently associated with infections in immunocompromised and critically ill patients. The prevalence of nonalbicans Candidaspecies and the rise of antifungal resistance have rendered infections from Candidaspecies increasingly difficult to treat. This study was carried out with the goal of examining the distribution, virulence features, and the susceptibility patterns for antifungals in different human clinical specimens for Candidaspecies obtained at tertiary teaching beds. Methodology: A cross-sectional study was performed on 174 clinical samples processed for isolation and identification of Candidaspecies using standard microbiological techniques. Antifungal susceptibility testing was performed using the disk diffusion method, and the presence of virulence factors such as biofilm formation and coagulase activity was assessed. Results: C. albicans was the foremost habitually confined species (52.9%), taken after by C. tropicalis (20.7%), C. glabrata (12.1%), and C. parapsilosis (8.6%). Antifungal helplessness testing uncovered tall defenselessness rates to amphotericin B, caspofungin, and micafungin, whereas diminished helplessness to fluconazole and voriconazole was watched, especially in C. glabrata. Biofilm arrangement, coagulase movement was related with expanded antifungal resistance, particularly to azoles. The dispersion of harmfulness variables was generally steady over distinctive clinical examples. Conclusion: The findings of the study indicated that C. albicans is the prevalent strain, while non-albicans species are on the rise. The study underscored the significance of considering virulence factors when addressing candidiasis. It also emphasized the importance of monitoring resistance to antifungal medications and creating therapies that focus on specific virulence mechanisms to enhance patient outcomes. The study proposed that future research should focus on extensive, long-term studies involving multiple facilities and delve into the molecular basis of virulence factor expression and antifungal resistance in Candidaspecies.

 
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