Background: Lichen planus is a chronic inflammatory disease that affects the skin, hair follicles, nails, and mucosa Mucosal surfaces affected include the oral, genital, ocular, otic, esophageal surfaces, and in rarer instances, the bladder, nasal, laryngeal, and anal surfaces. Materials and methods: A prospective case-control study was conducted to investigate a potential link between lichen planus (LP), leptin levels, and blood fat profile. They recruited 40 patients with LP and 40 healthy controls ensuring participants with LP were not on recent medications and had no other health conditions that could influence the results. Data analysis was performed using SPSS. Results: Significant alteration of lipid profile and leptin levels occur among lichen planus patients. Conclusion: Elevated levels of leptin, known as hyperleptinemia, have been linked to lichen planus (LP) and may play a role in its development or severity.