Background: The deviated nasal septum is one of the most common causes of unilateral nasal obstruction. The present study was conducted to assess effect of septoplasty in relieving nasal obstruction and on quality of life. Materials & Methods: 85 patients with deviated nasal septum of both genders were enrolled. NOSE questionnaire and diagnostic endoscopy was done. Results: Out of 85, males were 55 and females were 30. Pre- operatively and post- operatively, anterior deviation was seen in 25 and 6, posterior deviation in 26 and 5, septal spur in 17 and 2, high DNS in 9 and 1 and hypertrophied inferior turbinate in 8 and 1 respectively. Pre- operatively and post- operatively, symptoms score for nasal congestion was 2.5 and 0.6, for nasal blockage was 3.1 and 1.5, trouble breathing through nose was 2.9 and 1.2, trouble sleeping was 1.7 and 0.9 and unable to get enough air through nose during exercise or exertion was 2.7 and 2.9 and NOSE score was 64.2 and 9.8 respectively. The difference was significant (P< 0.05). Conclusion: Nasal obstruction symptom evaluation (NOSE) questionnaire effectively assessed the improvement in quality of life among the symptomatic patients.