Abstract Issue

Volume 13 Issue 6 (June) 2024

Original Articles

Clinico-biochemical, ultrasonographic profile and etiology of acute viral hepatitis in hospitalized children: A cross-sectional study
Dr. Shobhit Hari Gupta, Dr. Chandra Madhur Sharma, Dr. Ravish Kumar

Background: Hepatitis is a significant public health issue worldwide, including in India, with various viral agents causing acute viral hepatitis (AVH). This study aimed to analyze the etiology, clinical features, laboratory parameters, and sonological findings of AVH in children. Methods: A cross-sectional study was conducted at the Department of Paediatrics, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, from November 2022 to October 2023. A total of 104 pediatric cases of acute viral hepatitis, aged 1-18 years, were included. Clinical evaluation, laboratory investigations, and ultrasound findings were recorded. Results: The majority of cases (89.42%) were attributed to Hepatitis A virus (HAV). Clinical features included jaundice (88.5%), loss of appetite (86.5%), hepatomegaly (77.9%), fever (71.2%), and vomiting/nausea (66.3%). Serum bilirubin was deranged in 84.6% of cases. Ultrasonography revealed hepatomegaly (88.6%), gall bladder sludge (41.3%), and splenomegaly (28.8%). Acute liver failure occurred in 14 cases, with a mortality rate associated with severe cases. Conclusion: AVH, primarily caused by HAV, remains a significant health burden in India. Prevention strategies focusing on improved sanitation, clean water supply, and universal immunization against HAV and HBV are crucial to reduce morbidity and mortality.

 
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