Original Articles
Study of maternal thyroid hormone status in preeclampsia and normal pregnancy | |
Dr. Vanshika, Dr. Rita Thakur | |
Aim: The present study is being done to evaluate thyroid hormones status in normal pregnancy andpreeclamptic women and correlate it with the severity of preeclampsia.Materials and Methods: A case control study was done on age and parity matched 100 preeclamptic women and 100 normotensive women in their third trimester. Serum free T3, T4, TSH were evaluated in both the groups. Their prevalence and their association with the severity of pre-eclampsia was also seen.Results: Most of the patient in cases group were primigravida i.e.,-53% vs 43% in controls. In this study, Prevalence of thyroid dysfunction in preeclamptic women is 48%.Among these patients, 42% patients had subclinical hypothyroidism, 4% had over thypothyroidism and 2% had hyperthyroidism. Severe preeclampsia was seen is 17 (17%) patients, out of which 10 (58.8%)were subclinical hypothyroid, 3 (17.6%) were overt hypothyroid and 1 (0.05%) was of hyperthyroid. The mean TSH value in the preeclamptic group (PE) is more than the controls in our study (2.91±1.69 Vs 2.33 ± 1.33) and is significant (p=0.007) The mean free T4 values in our study in preeclampsia Vs controls is 0.97 ±0.29 Vs1.07 ±0.40 which is significant.Conclusions: Hypothyroidism maybeamodifiableriskfactorforpreeclampsia. Maternal markers of hypothyroidism should be controlled at early stages of pregnancy to minimize risk for not only hypothyroidism but also for development of preeclampsia. |
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