Introduction: Polycystic ovary syndrome (PCOS) is a reproductive disorder of growing concern in women of child bearing age group. The presence of metabolic and endocrine disorder along with the reproductive derangement necessitates a multiomics approach to understand its pathophysiology. The adipocytokines have been quite instrumental in this aspect of learning about the metabolic defects in PCOS. VASPIN a visceral adipose tissue derived adipokine is a novel molecule which has been associated with metabolic syndrome, is being researched in PCOS. Objective : We aim at studying the serum VASPIN levels in PCOS patients and correlate them with BMI, plasma insulin, HOMA-IR in these patients. Material and Methods: 90 participants were included in the study with 60 PCOS patients (30 women with BMI≥ 25 and 30 women with BMI 25 and 30 women with BMI and 30 age matched healthy controls. Anthropometric measurements were done. Fasting blood glucose, plasma insulin, Homeostatic model assessment for insulin resistance (HOMA-IR), serum vaspin levels were measured. All data were analysed using IBM SPSS version 20 and presented as mean and standard deviation(±SD), ANOVA and Pearson’s correlation was done. Result : There was no significant difference between the age in the three groups. The fasting blood glucose, plasma insulin, HOMA -IR were significantly higher in both lean and obese PCOS groups compared to the controls. The mean of serum VASPIN level in obese PCOS (4.06 ± 2.39) and lean PCOS (1.47 ± 0.28)was higher than control (1.06 ± 0.35) which was statistically significant. (p< 0.001). The Serum VASPIN level positively correlated with BMI, plasma insulin, HOMA –IR in both obese and lean PCOS. Conclusion : The increase in serum VASPIN levels and its positive correlation with BMI, HOMA-IR and plasma insulin in PCOS patients could contribute to the diabetogenic ,atherogenic and steroidogenic risk in PCOS. Therefore VASPIN could be a good diagnostic and predictive marker to prevent the complication in PCOS.