Background: Nd:YAG laser capsulotomy is a widely accepted safe, effective and quick procedure to treat PCO. However, it comes with its own complications and therefore, it is imperative to assess the anterior and posterior chamber before and after the procedure. Aims and Objectives: To assess the changes in refraction, intraocular pressure, anterior chamber depth and angle after Nd:YAG laser capsulotomy. Materials and methods: 50 eyes with significant PCO after an uneventful cataract surgery were taken and complete ocular examination was done including slit lamp and fundus examination. Visual acuity assessment by Snellen’s chart, IOP measurement by GAT and anterior chamber assessment using anterior segment OCT was carried out in all patients before laser and post-laser at 1 hour, 1 week and 1 month . Capsulotomy was done using VISULAS YAG III Q-switched Nd:YAG laser machine by Zeiss. Results: There was a statistically significant improvement in BCVA in all patients. 56% patients had BCVA 6/6, 32% patients had BCVA 6/9 and rest 6% patients had BCVA 6/12 and 6/18. A statistically significant rise in IOP was observed at 1 hour following laser which was >5mmHg. The mean value pre-laser was 12.58, and after 1 hour it was 18.34. Thereafter, there was a sharp decline in IOP and mean value after 1 week was 12.88, and after 1 month was 12.52. Repeated measure ANNOVA showed that the anterior chamber depth increased significantly from pre-laser to 1 hour and from 1 week to 1 month. Conclusion: Our study showed that visual acuity improved in all subjects after capsulotomy. A sharp spike in IOP post-laser was observed which declined gradually and attained baseline value in a some time. So, anti-glaucoma medications should be given in glaucomatous, aphakic, and high risk patients. An increase in anterior chamber depth is a significant finding and causes change in refraction.