Background:One of the most prevalent fractures is the distal radius fracture (DRF), and its frequency is steadily rising. The present study was conducted to assess complex regional pain syndrome in association with fracture distal radius reduction method. Materials & Methods:104 patients with distal radius fractures of both genders. All were informed regarding the study and their written consent was obtained. Data such as name, age, gender etc. was recorded. Am thorough clinical and physical examination was carried out. Patients were divided into 2 groups based on incidence of complex regional pain syndrome (CRPS). Group I had CRPS and group had not. Risk factors were recorded. Results: Reduction method used was open in 16 and 32 and closed in 18 and 38. Application of external fixator was done in 7 and 15, with ulnar fracture in 11 and 17 and with open fracture in 12 and 20 patients in group I and II respectively. The difference was significant (P< 0.05). Risk factors for CRPS was mean age (years), seropositive RA, reduction method, with ulnar fracture and open fracture (P< 0.05). Conclusion: The incidence of CRPS-1 following DRF surgery was low. Patients with rheumatoid arthritis and difficult fractures who are susceptible to developing CRPS-1 require close observation.