Aim: The aim of the present study was to correlate the dry eye and diabetic retinopathy with duration of diabetes and blood urea and serum creatinine level.Material & Methods:A prospective clinical observational study was conducted for a period of 2 years.A written consent was obtained from the patients before subjecting them for detailed clinical examination. 200 cases of only type 2 diabetes mellitus patients who reported to eye OPD through referral from diabetology OPD and ward, medicine OPD and ward for routine diabetes eye screening were examined.Results: Out of 200 patients, 132 were female and 68 were male. Patients with diabetes duration under 1 year were 6%. 59% of the population was 1-5 years diabetes duration. 35% had dry eyes and 65% did not. 25% of patients had FBS <110mg/dl. 75 percent had FBS over 110mg/dl. 52 individuals had PPBS under 160 mg/dl. 148 had PPBS over 160 mg/dl. 172 individuals had blood urea below 40 mg/dl. 28 patients had blood urea over 40 mg. 180 individuals had serum creatinine <1 mg/dl. 20 individuals had serum creatinine >1 mg/dl. 16 of 60 Schirmer test positives had diabetes for 1-5 years. 20 had 6-10 years of diabetes. 16 had 11-20 years of diabetes. The aforementioned comparison P value was significant. 8 of 50 TBUT-positive patients had diabetes for 1-5 years, 32 for 6-10 years, and 10 for 11-20 years.Conclusion: A statistically significant positive link existed between dry eye, diabetes duration, and retinopathy severity. Therefore, all diabetics should be examined for retinal alterations and ocular surface problems immediately and treated. Treating ocular surface problems and diabetic retinopathy early prevents consequences. Maintaining glycemic control and timely follow-up should be stressed.