Aim: The purpose of this study is effect and role of Atorvastatin in suppressing Tumor growth of Uterine Fibroids , Endometrium Thickness and Clinical symptoms of patient . Methods Initially, We conducted a retrospective study of 100patients with uterine fibroids . Then, we evaluated the effect of atorvastatin on proliferation and apoptosis both in immortalized uterine fibroids cells and primary uterine fibroids cells. Furthermore, the molecular mechanism by which atorvastatin suppressed uterine fibroids cell growth was explored. Results:Our results showed that atorvastatin use for 1 years significantly suppressed growth of uterine fibroids. Uterine fibroid demonstrated significant reduction in size as well as significant changes following the atorvastatin treatment after 6 months in a dose dependent manner, while endometrial thickness demonstrated insignificant differences as measured by transvaginal ultrasound (TVS). Atorvastatin inhibited the proliferation of immortalized and primary uterine fibroids cells in a dose and time-dependent manner and stimulated apoptosis of uterine fibroids Conclusions: The current study demonstrated that atorvastatin exerts anti-tumoral effects on uterine fibroids and has promising effects in cases with uterine fibroids as it was associated with a reduction of fibroid size Our results provide the first clinical and preclinical data on the use of atorvastatin as a promising nonsurgical treatment option for uterine fibroids.According to the present study there is also in reduction in clinical symptoms of patient as well as effective on reduction of endometrium thickness