Background: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition characterized by pelvic pain and urinary symptoms. Histopathological examination of bladder tissue may provide valuable insights into the pathogenesis and management of IC/BPS. However, the clinical relevance of bladder histopathological findings and their impact on treatment outcomes remain poorly understood. Materials and Methods: We conducted a retrospective study at NMCH, Jamuhar, Sasaram, Bihar, to evaluate the clinical relevance of bladder histopathological findings among patients with IC/BPS. A total of 24 patients diagnosed with IC/BPS who underwent bladder biopsy between July 2023 and April 2024 were included in the study. Histopathological analysis was performed to assess for findings such as urothelial denudation, inflammation, fibrosis, and other pathological changes. Treatment outcomes, including symptom improvement and recurrence rates, were assessed based on medical records and patient follow-up over a 10-month period. Results: Among the 24 patients included in the study, histopathological examination revealed various findings consistent with IC/BPS pathology, including urothelial denudation (n=18, 75%), inflammation (n=20, 83%), and fibrosis (n=14, 58%). Treatment outcomes varied among patients, with 14 patients (58%) experiencing symptomatic improvement following treatment, while 10 patients (42%) experienced recurrence of symptoms during the 10-month follow-up period. Patients with severe histopathological changes, such as extensive inflammation and fibrosis, tended to have poorer treatment outcomes compared to those with milder histopathological findings. Conclusion: Bladder histopathological findings in patients with IC/BPS can provide valuable clinical information regarding disease severity and treatment response. Our study suggests that patients with more severe histopathological changes may have a higher risk of treatment failure and symptom recurrence. Further research is warranted to better understand the relationship between histopathological findings, treatment outcomes, and long-term prognosis in patients with IC/BPS.