Aim:To compare the effectiveness of subcutaneous negative pressure with simple closure of the skin incision in patients undergoing surgery for hollow viscus perforation. Material and methods:The research comprised a total of 100 patients who were admitted to the Department of General Surgery. The participants were thereafter assigned in an alternating manner to either Group A, which received a subcutaneous closed suction drain, or Group B, which did not get a drain. Prior to the surgery, the surgical site was sterilized with povidone iodine and alcohol in the operating room. A midline incision was made to open the abdomen. Following the surgical operation, a comprehensive peritoneal lavage was administered. Results: Thirteen individuals, which accounts for 26% of the total of 50 patients, had complications connected to their wounds. Among the 50 patients who had primary skin closure, 27 patients (54%) experienced local complications at the surgical site, as shown in Table-2. The incidence of complications in individuals with a subcutaneous drain was considerably low, with a P value of 0.03.The predominant complication seen was Surgical Site Infection, with a prevalence of 12% in group A and 32% in group B. In the current investigation, additional postoperative complications such as wound dehiscence (7%) and ruptured abdomen (3%) were identified. Three patients in Group B had a ruptured abdomen accompanied by the protrusion of colon. The average length of hospitalization for patients with subcutaneous negative pressure drain was 9.53±1.76 days. The mean length of hospitalization for patients who did not have a drain was 12.87±1.98 days. Conclusion: Our research demonstrates that the use of subcutaneous negative pressure drainage effectively decreases the occurrence of surgical site infection and shortens the length of hospitalization after surgery for hollow viscus perforation. This intervention facilitates prompt recovery, enhances wound healing, and reduces the financial burden on patients by minimizing hospitalization and infection.