Background: Stress urinary incontinence (SUI) is a common condition characterized by the involuntary leakage of urine during activities that increase abdominal pressure, such as coughing, sneezing, laughing, or physical exertion. The present study was conducted to assess efficacy of duloxetine in stress urinary incontinence in women. Materials & Methods: 48 women with stress urinary incontinence of both genders. All were informed regarding the study and their written consent was obtained. Data such as name, age, etc. was recorded. Patients received duloxetine 20 mg twice daily for 12 weeks. The variables included the IEF and improvement in quality of life.Incontinence episode frequency/week (IEF/week) was recorded. Results: IEF at baseline was 12.8, after 1month was 95, after 2 months was 7.2 and after 3 months was 6.4. IEF at baseline in patients those shows improvement was 12.7 and those not responding was 13.5 and at 1 month in in patients those shows improvement was 9.1 and those not responding was 12.7. The difference was non- significant (P> 0.05).PGI- I score 1 was seen in 29%, score 2 in 37% and score 3 in 34%. The difference was significant (P< 0.05). Conclusion: Duloxetine is a potential treatment for women with stress urinary incontinence.