It is indisputable that adequate and appropriate nutrition is fundamental to the health, growth, and development of infants, children, and adolescents, including those with cancer. Nutrition has a role in most of the accepted components of the cancer control spectrum, from prevention through to palliation. Nutritional status in children with cancer is an important prognostic factor. Assessment consisting of anthropometry, biochemistry, clinical, and diet that needs to be done on diagnosis and regularly to ensure that patient’s nutritional status does not deteriorate. In developing countries, assessment will depend on the availability of all resources, but monitoring is essential. The development of malnutrition during treatment is possible and the reasons are multi factorial. Nutrition plays a deciding role and a key factor in children with cancer and can influence their outcome. Materials and methods: This, first of its kind study on understanding the impact of nutritional intervention on pediatric oncology patients was conducted in the medical oncology department of Sher-I- Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, J&K – India, from May 2018 to September 2022. Anthropometric measurement, demographic profiles, and etiological analysis were done and collected pre and post intervention. Food frequency tables were also put forward. Besides these, personal interviews and observation methods were also used. Results: Nutritional interventions had a measurable positive outcome on the nutritional profiles of the pediatric oncology patients in SKIMS, Soura, Srinagar – India. The grades of nutritional status substantially improved from 51.20%, 12.30%, 6.59%, 3.51%, 7.03%, 6.15%, 14.90%,2.63%, 2.19% of the well-nourished, mildly malnourished, moderately malnourished, severely malnourished, mild thinness, moderately thinness, severe thinness, overweight and obese to 61.53%, 9.89%, 4.39%, 2.19%, 6.37%, 4.39%, 7.69%, 1.97%, and 1.53% respectively, clearly indicating that with appropriate dietary advice and interventions there is a significant impact on improving the grade of malnutrition.