Background: Biliary obstruction commonly refers to blockage of the bile duct system leading to impaired bile flow from the liver into the intestinal tract. It has been exactly two decades since magnetic resonance cholangiopancreatography (MRCP) was first described. Hence; the present study was conducted for assessing the diagnostic accuracy of computed tomography (CT) and magnetic resonance cholangiopancreatography (MRCP) in detecting calculi related obstruction in the common bile duct (CBD). Materials & methods: A total of 50 patients were enrolled. Inclusion criteria for the present study included patients admitted with biliary disease, with scleral and tegumentary jaundice and high bilirubin levels; patients may have had prior cholecystectomy. Examination of the patients was done by CT and MRCP. Postoperative findings were evaluated and histopathologicdiagnosis were analyzed. Results: Mean age of the patients was 48.3 years. 82 percent of the patients were males while remaining were females. CT scan was able to detect caliculi in 78 percent of the cases while MRCP was able to detect in 100 percent of the cases. Sensitivity of CT and MRCP in diagnosing obstruction by calculi was 88.2 percent and 100 percent respectively while Specificity of CT and MRCP in diagnosing obstruction by calculi was 100 percent and 100 percent respectively. Conclusion: The diagnostic accuracy of MRCP was higher than CT for assessing calculi related obstruction of common bile duct.